Key Publications

Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer’s disease 

Rajani R.M.✉, Ellingford, R., Hellmuth, M., Harris, S.S., Taso, O.S., Graykowski, D., Lam, F.K.W., Arber, C., Fertan, E., Danial, J.S.H., Swire, M., Lloyd, M., Giobannucci, T.A., Bourdenx, M., Klenerman, D., Vassar, R., Wray, S., Sala Frigerio, C., and Busche, M.A.✉

PLoS Biology (2024)

Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats 

Rajani, R.M., Quick, S., Ruigrok, S.R., Graham, D., Harris, S.E., Verhaaren, B.F.J., Fornage, M., Seshadri, S., Atanur, S.S., Dominiczak, A.F., Smith, C., Wardlaw, J.M., and Williams, A. 

Science Translational Medicine (2018)

Blood brain barrier leakage is not a consistent feature of white matter lesions in CADASIL 

Rajani, R.M., Ratelade, J., Domenga-Denier, V., Hase, Y., Kalimo, H., Kalaria, R.N., and Joutel, A. 

Acta Neuropathologica Communications (2019)

Characterisation of early ultrastructural changes in the cerebral white matter of CADASIL small vessel disease using high-pressure freezing/freeze-substitution 

Rajani, R.M., Dupré, N., Domenga-Denier, V., Van Niel, G., Heiligenstein, X., and Joutel, A. 

Neuropathology and Applied Neurobiology (2021)

Selectively vulnerable deep cortical layer 5/6 fast-spiking interneurons in Alzheimer’s disease models in vivo

Papanikolaou, A., Graykowski, D., Lee, B.I., Yang, M., Ellingford, R., Zünkler, J., Bond, S.A., Rowland, J.M., Rajani, R.M., Harris, S.S., Sharp, D.J., and Busche, M.A.

Neuron (2025)

Alzheimer’s disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons

Harris, S.S., Ellingford, R., Hartmann, J., Dasgupta, D., Kehring, M., Rajani, R.M., Graykowski, D., Quittot, N., Sivasankaran, D., Commins, C., Fan, Z., Bond, S.A., Wolf, F., Dupret, D., Dolan, R.J., Konnerth, A., Neef, A., Hyman, B.T., and Busche, M.A.

Cell (2025)

Characterization of early white matter changes in CADASIL using microscopic diffusion imaging and relaxometry 

Barrière, D.A., Uszynski, I., Rajani, R.M., Gueniot, F., Domenga-Denier, F., Boumezbeur, F., Poupon, F., and Joutel, A. 

bioRxiv (2023)

A vessel for change: endothelial dysfunction in cerebral small vessel disease

Quick, S., Moss, J., Rajani, R.M., and Williams, A.

Trends in Neurosciences (2020)

Deep-learning based segmentation of challenging myelin sheaths 

Le Couedic, T., Caillon, R., Rossant, F., Joutel, A., Urien, H., and Rajani, R.M. 

2020 Tenth International Conference on Image Processing Theory, Tools and Applications (IPTA) (2020)

Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology 

Horsburgh, K., Wardlaw, J., van Agtmael, T., Allan, S., Ashford, M., Bath, P.M., Brown, R., Berwick, J., Zameel Cader, M., Carare, R.O., Davies, J.B., Duncombe, J., Farr, T.D., Fowler, J., Goense, J., Granata, A., Hall, C., Hainsworth, A., Harvey, A., Hawkes, C., Joutel, A., Kalaria, R., Kehoe, P.G., Lawrence, C., Lockhart, A., Love, S., Macleod, M., Macrae, M., Markus, H.S., McCabe, C., McColl, B.W., Meakin, P.J., Miller, A., Nedergaard, M., O’Sullivan, M., Quinn, T., Rajani, R., Saksida, L., Smith, C., Smith, K.J., Touyz, R., Trueman, R.C., Wang, T., Williams, A., Williams, S., and Work, L.

Clinical Science (2018)

Endothelial cell–oligodendrocyte interactions in small vessel disease and aging 

Rajani, R.M., and Williams, A. 

Clinical Science (2017)